Welcome to the Week in Review.
P4ADNOW and AARP Send Letter on OPRHAN Cures to Senate
To safeguard hard-fought and cost-saving drug price reforms, P4ADNow and AARP sent a joint letter to all Senators to oppose the inclusion of the ORPHAN Cures Act in the reconciliation bill. At a time when nine in ten Americans want further action from Congress to lower the price of prescription drugs and an overwhelming majority support giving Medicare the power to negotiate lower drug prices for ALL drugs, including this policy in the reconciliation package would be a step backward. The Congressional Budget Office (CBO) found that the ORPHAN Cures Act would increase federal spending by $4.87 billion over the next 10 years. That’s billions of dollars going straight into the pockets of big drug companies. We’re urging Congress to put patients first rather than bend to the whims of greedy drug manufacturers. — [P4ADNow, AV, CBO]
Most Favored Nation: One Month Out
This week marked 30 days since President Trump issued his executive order to align U.S. drug prices with other high-income nations through the “Most-Favored-Nation” (MFN) approach. In the U.S., drug companies charge Americans between four and eight times what patients in other high-income countries pay for the very same brand-name drugs because the current system lets them. If done right, international referencing pricing could help lower prices in the U.S. But as expected, Big Pharma is already pushing back hard. Pfizer and other drugmakers met with the administration, but failed to make any commitments to lower prices. Instead, Pfizer CEO and PhRMA Board Chair Albert Bourla said he hopes prices in Europe increase, even threatening to pull drugs from some countries if they don’t pay more. We’ve said it before: any proposal that seeks to raise prices abroad is a nonstarter. The real problem is that the U.S. has failed to rein in the pharmaceutical industry. Americans know who the drivers of high drug prices are, and pharma’s recent comments make it even clearer where their priorities lie. — [White House, P4ADNow, Quartz, Reuters]
Spotlight on Cell and Gene Therapies
The heads of HHS, FDA, NIH, and CMS came together for a roundtable discussion on the future of cell and gene therapies, where NIH Director Jay Bhattacharya emphasized the importance of making these life-saving treatments both scalable and affordable. Treatments like these have been critical for patients like Janet Kerrigan, whose CAR-T therapy put her multiple myeloma into remission. But no one should be saddled with the enormous price tags these innovations currently carry, which can reach nearly $3 million for disorders like sickle cell. Lowering this cost is a priority, and we’re encouraged to hear that affordability might also be on the radar for federal leaders as they chart the path forward. — [Endpoints News, P4AD, Ortho]
In Case You Missed It
On Monday, the FDA announced it would be reinstating the internal team responsible for advancing generic drug approvals, reversing its controversial decision to dismantle the office earlier this year. As Endpoints News noted, the team played a key role in driving the agency to a record number of new generic drug approvals before its elimination in April. — [BioSpace, Endpoints News, Pink Sheet]
Subscribe to the WEEK IN REVIEW here.
Welcome to the Week in Review.
Fighting ORPHAN Cures in the Senate
As the Senate considers the House-passed reconciliation package, P4ADNow is urging lawmakers to reject the inclusion of the ORPHAN Cures Act — an unnecessary Pharma handout that would weaken the effective and popular Medicare Negotiation Program. At a time when nine in ten Americans want further action from Congress to lower drug prices and an overwhelming majority support giving Medicare the power to negotiate lower drug prices for every drug, including this policy that would reduce the number of drugs eligible for negotiation would be a harmful step backward. The Congressional Budget Office (CBO) found that the bill would cost taxpayers $4.8 billion over the next 10 years. That’s nearly $5 billion in lost savings — not to support innovation or new treatments, but to allow drug companies to keep prices high for longer at the expense of patients. Americans know that Pharma is to blame for their high drug prices, and over the coming days, P4AD patient advocates who would be impacted by this legislation will be speaking to their Senators to express their strong opposition to the ORPHAN Cures Act. — [Axios, CMS, CBO]
The Tide Continues to Turn Against PBMs
Arkansas is taking on PBMs with its first-in-the-nation law barring PBMs from owning pharmacies in the state. The profitability of PBMs has risen in recent years as a result of vertical mergers between PBMs, insurance companies, and pharmacies, leading to higher prices for patients. Arkansas’ law represents a major step toward dismantling these vertically integrated monopolies that contribute to keeping prices artificially high. While PBMs claim to be utilizing their bargaining power on behalf of patients, they’ve simultaneously fought to ensure their rebate practices stay hidden from view. As Axios reported, “the ramifications are nationwide, with many other states weighing new restrictions, including prohibitions on steering business to affiliated pharmacies.” — [Axios, Axios, Reuters, Pharmacy Times]
Supporting Transparency in Drug Advertisements on Capitol Hill
On Thursday, Reps. Dave Taylor (R-OH) and Jan Schakowsky (D-IL) introduced the Drug-Price Transparency for Consumers Act of 2025, companion legislation to the Senate version that would mandate pharmaceutical companies disclose the cost of their drugs in all direct-to-consumer (DTC) advertising. This joins the growing trend against DTC Pharma advertising, after Senators Josh Hawley (R-MO) and Jeanne Shaheen (D-NH) introduced the bipartisan and P4ADNow-endorsed No Handouts for Drug Advertisements Act last month. The U.S. is one of only two countries that allows DTC advertising for pharmaceutical drugs, and the least patients deserve is transparency on the cost of what’s being advertised to them. P4ADNow endorsed this bill, and is supportive of efforts to bolster transparency at all steps of the pharmaceutical process. — [Washington Examiner]
In Case You Missed It
This week, P4AD attended Latino Magazine’s LATINO 100 luncheon. Latino patients are more likely to report difficulty affording prescription medications, and Gallup polling earlier this year found that Hispanic adults are reporting the greatest increase in lack of ability to afford or access quality healthcare. P4ADNow is working closely with organizations and groups who serve the Latino community as part of our push to expand our community in the fight to lower drug prices.
Subscribe to the WEEK IN REVIEW here.
Welcome to the Week in Review.
Expanding Medicare Negotiation with the SMART Prices Act
The Strengthening Medicare and Reducing Taxpayer (SMART) Prices Act has been re-introduced by Senators Amy Klobuchar (D-MN) and Peter Welch (D-VT) — legislation that will expand Medicare price negotiation and strengthen HHS’ tools to lower prescription drug prices. One in three Americans can’t afford their prescription drugs, and we hear from patients every day who are rationing medication or skipping doses because of high drug costs. The SMART Prices Act builds on the 2022 prescription drug law’s historic drug price reforms by increasing the number of drugs subject to Medicare negotiation — a proposal that has broad support from Americans on both sides of the aisle. Patients For Affordable Drugs NOW endorses this legislation, and we support efforts to expand Medicare negotiation to secure a better deal for even more Americans. — [Senator Klobuchar, Senator Welch]
Trump’s “Most Favored Nation” Proposal Keeps Moving
The administration’s “Most Favored Nation” (MFN) policy begins to take shape this week, with President Trump tapping CMS administrator Dr. Mehmet Oz to lead the negotiations process. Americans pay the highest drug prices in the world, and international reference pricing frameworks like MFN are worth exploring — but only if they’re done right. The policy must meaningfully lower prescription drug prices for U.S. patients, without driving up costs in other countries or creating new loopholes for drug companies to exploit. This also means a policy that’s developed in conjunction with Congress to ensure reference prices are enforceable and stand up to legal scrutiny. P4ADNow will continue monitoring as this policy develops. — [Endpoints News, BioSpace, JAMA Health Forum, Axios]
RFK Jr. vs. Big Pharma’s TV Ads
The U.S. and New Zealand are the only two countries in the world that allow direct-to-consumer (DTC) advertising by drug manufacturers. HHS Secretary RFK Jr. has long criticized this practice, and his renewed calls to ban pharma ads from TV gained fresh attention this week. Making matters worse, taxpayers are subsidizing these ads through a longstanding tax break that has allowed Big Pharma to flood the airwaves for years. Earlier this month, Senators Josh Hawley (R-MO) and Jeanne Shaheen (D-NH) introduced the bipartisan and P4ADNow-endorsed No Handouts for Drug Advertisements Act, which would eliminate that tax break — a common-sense step toward curbing pharma’s outsized influence. — [X.com, Bloomberg, Senator Hawley]
Subscribe to the WEEK IN REVIEW here.
Welcome to the Week in Review.
P4AD Report Exposes Pharma-Funded Groups Doing the Industry’s Bidding
As the fight to lower drug prices heats up on Capitol Hill, P4AD released a new report, The Rampant Reach of Pharma’s Hidden Hand, uncovering the pharmaceutical industry’s efforts to fund, influence, and in some cases, fully operate, front groups that claim to represent the interests of patients while working to protect drug company profits. The research is a continuation of P4AD’s multi-year investigation into pharma’s behind-the-scenes manipulation of public debate on drug pricing, building on our 2021 and 2023 reports with six new industry-backed organizations: the Alliance for Aging Research, the American Action Forum, the Center for Medicine in the Public Interest, the Council for Affordable Health Coverage, the Pacific Research Institute, and Seniors 4 Better Care. Each group claims to advocate for patients, but their real mission is clear: protect drug industry profits and delay or derail reforms that would bring prices down. If these groups truly advocated for patients, they’d listen when 90% of Americans demand more action to lower drug prices. — [P4AD Report, Arnold Ventures, Common Dreams, Truthout, The Lever]
Centering Patient Stories at CHCI
P4AD’s Executive Director, Merith Basey, joined the Congressional Hispanic Caucus Institute’s (CHCI) annual Health Summit to discuss reforms to improve prescription drug access among Latino communities and ensure patient stories were front and center. America is in the midst of a drug pricing crisis, and the panel, “Balancing Drug Affordability and Innovation: Ensuring Access While Advancing Research,” was a conversation with representatives from PhRMA and researchers on the reforms needed to fix a system rigged against patients. The pharmaceutical industry deserves to be held accountable for its role as the true driver of high prices, and Merith stood up for patients throughout the conversation. Innovation and affordability aren’t opposing forces, but with 29 million Americans now considered “cost-desperate” when it comes to their medication, it’s clear that we need to take real steps to rein in monopoly pricing, increase transparency, and expand Medicare negotiation. Drugs don’t work if people can’t afford them, and there’s no value in medical breakthroughs that patients can’t access. — [CHCI, Gallup]
The ORPHAN Cures Act Will Cost Taxpayers Billions
The ORPHAN Cures Act is an unnecessary giveaway to the pharmaceutical industry, and it would cost taxpayers billions. On Thursday, the House passed a reconciliation package that includes this harmful provision, which would weaken Medicare’s ability to negotiate lower drug prices by exempting more drugs or delaying their eligibility. Just months before the first negotiated prices are set to take effect, lawmakers added a costly loophole that would delay relief for patients and add $4.8 billion to taxpayer costs over the next decade, according to the Congressional Budget Office (CBO). The bill now moves to the Senate, and P4ADNow urges lawmakers to reject this deeply flawed legislation. Including ORPHAN Cures and its multibillion-dollar price tag in the final package would be a serious mistake. — [Congress.gov, CBO, P4ADNow, Fierce Healthcare]
ICYMI
HHS announced targets for pharmaceutical companies following President Trump’s “Most Favored Nation” executive order last week. As always, the devil is in the details, and P4ADNow will be watching closely as this policy continues to develop.
Subscribe to the WEEK IN REVIEW here.
Welcome to the Week in Review.
Trump Revives Global Drug Pricing Debate
This week, President Trump issued an Executive Order (EO) focused on addressing the high cost of prescription drugs. One key provision aims to align U.S. prices with those in other high-income nations — a concept referred to as “Most Favored Nation” (MFN). Right now, Americans pay the highest drug prices in the world for two main reasons: U.S. policy allows drug companies to set launch prices and raise them at will, and unlike other countries that negotiate prices for nearly all prescription drugs, the U.S. only recently began limited negotiation for a small set of expensive drugs through Medicare. That’s why international reference pricing frameworks like MFN are worth exploring — but only if they’re done right. P4ADNow supports pursuing a better deal for Americans — including through the widely popular Medicare Negotiation program — however, any MFN policy must meaningfully lower prices for U.S. patients, without driving up costs or limiting access abroad, and should include strong guardrails to prevent drug companies from exploiting new loopholes. Check out P4ADNow’s Executive Director Merith Basey’s interview on the EO on Univision. — [New York Times, Forbes, Epoch Times, Citeline, Healthcare Finance, STAT News, Endpoints News, Reuters, POLITICO, Washington Post, Bloomberg Law, USA Today]
Another Win for Patients and Another Warning For Big Pharma In Court
Patients netted a massive victory this week, after the U.S. Court of Appeals for the Third Circuit rejected AstraZeneca’s challenge to the Medicare Drug Price Negotiation Program in a unanimous ruling — affirming that Medicare can and should be negotiating lower drug prices on behalf of seniors and people with disabilities. This ruling marks the first appellate decision evaluating and upholding the negotiation program’s core framework, and it serves as a warning to other drug companies attempting to protect their outrageous profits through the court. As Michael Lieberman of Fairmark Partners — the firm representing P4AD in amicus briefs — told Inside Health Policy, the decision is a “positive sign for the government regarding how the Third Circuit might rule in other cases.” To date, P4AD has submitted four amicus briefs on behalf of patients and has signed onto seven amicus briefs in our campaign to challenge Big Pharma’s attempts to undermine Medicare negotiation through the U.S. legal system. — [Endpoints News, Inside Health Policy, P4AD, Pink Sheet, Bloomberg Law, Reuters, FirstWord Pharma, Law360]
The ORPHAN Cures Act Would Undermine Patient Savings
On Wednesday, the House Energy and Commerce Committee advanced the ORPHAN Cures Act (H.R. 946), which was included in a larger reconciliation bill largely focused on Medicaid. Driven predominantly by the pharmaceutical industry and its allies, ORPHAN Cures would create an unnecessary loophole in the Medicare Negotiation Program, allowing even more drugs to avoid price negotiation — including those indicated for multiple rare diseases — right before the first round of negotiated prices takes effect in January. Medicare negotiation is on the verge of delivering $1.5 billion in savings to nine million patients and $6 billion in taxpayer savings, so the last thing Americans need is a new loophole for the pharmaceutical industry to exploit. Thousands of P4ADNow patient advocates have sent letters demanding Congress vote no on ORPHAN Cures, and P4ADNow is urging Congress to side with patients and stop the progression of this harmful bill. — [Congress.gov, CMS]
Endorsing the No Handouts for Drug Advertisements Act
On Wednesday, Senator Jeanne Shaheen (D-NH) and Senator Josh Hawley (R-MO) introduced the No Handouts for Drug Advertisements Act to eliminate a tax break that fuels the flood of prescription drug ads designed to boost profits for Big Pharma and drive up prices for patients. The U.S. is one of just two countries that even allows direct-to-consumer (DTC) drug advertising — there’s no reason taxpayers should be footing the bill for it. We’re proud to support Senators Shaheen and Hawley’s common-sense reform to put patients before pharma profits. — [Inside Health Policy]
ICYMI
Patients For Affordable Drugs’ founder and president, David Mitchell, has been included in Washingtonian’s Washington DC’s 500 Most Influential People of 2025 for the third year in a row. David’s commitment to reforming the drug price system without taking a penny from industry has made him one of the most trusted and influential voices on this issue.
Subscribe to the WEEK IN REVIEW here.
Welcome to the Week in Review.
Growing Momentum Around International Reference Pricing
Senators Josh Hawley (R-MO) and Peter Welch (D-VT) unveiled a bipartisan bill that would bar drug companies from charging Americans more than the international average price for a specific prescription drug, adding to growing momentum around international reference pricing. Meanwhile, the Trump administration is considering a separate proposal that would tie Medicaid drug payments to foreign prices as part of broader budget reconciliation legislation, with new reports that Trump is expected to sign an executive order pursuing the initiative as soon as Monday. P4AD supports the principle that Americans shouldn’t be paying up to eight times more than patients in other countries, and we’re encouraged to see bipartisan efforts to lower drug prices through mechanisms such as international reference pricing. These proposals have the potential to deliver real relief for patients, but ultimately, the devil will be in the details. We’ll be watching closely to ensure any final plan truly lowers prices without restricting access here or abroad. — [POLITICO, Stat News, Axios, Endpoints News, Bloomberg, POLITICO]
P4AD Holds Community Town Hall
On Tuesday, we hosted a live Town Hall to answer questions from our community and shared the latest in our fight to stop pharma, its lobbyists, and allies from rolling back the progress we’ve made to lower drug prices. We covered everything from the threats to Medicare negotiation, to the potential harm of tariffs, to recent competition bills progressing through Congress, to efforts to reform the PBM system. Thank you to our community members who joined us live and to those of you who wrote to us with close to 600 questions! If you missed it, check out the video here!
Drug Spending Hits Record High As Patients Struggle to Afford Medications
According to Axios’ coverage of a new IQVIA report, Americans’ out-of-pocket spending on prescription drugs has surged 25% over the last five years, reaching a historic high of $98 billion last year. Even though total net medicine spending rose 11.4% last year, hitting a massive $487 billion, more than one-quarter of new prescriptions went unfilled — largely because they aren’t covered by insurance. It’s no surprise that nearly 90% of voters, including 89% of Trump voters, say prescription drug prices are too high, with nearly 60% of Americans reporting struggling to afford their medications in the last 12 months. Americans – who pay between four and eight times more than people in other wealthy countries – are urgently demanding that the White House and Congress do more to address this crisis of high drug prices. — [Axios, Arnold Ventures]
ICYMI
In a powerful report for ProPublica, David Armstrong reflects on the cancer drug Revlimid — the same drug that helped treat his own multiple myeloma — and the industry tactics that kept its price high for years. The piece, which includes reflections from P4AD’s David Mitchell, who is also a multiple myeloma patient, captures both the human stakes and the corporate strategies that put profit above patients.
Subscribe to the WEEK IN REVIEW here.
Welcome to the Week in Review.
P4AD and AARP Push Back Against Pharma’s EPIC Act
In an exclusive first reported by The Hill, P4ADNow and AARP sent a joint letter to top House committee leaders urging them to reject the EPIC Act (H.R. 1492) — a pharmaceutical industry-backed bill that would delay Medicare drug price negotiation for small-molecule drugs from 9 to 13 years. The move comes as lawmakers consider what to include in the upcoming reconciliation package, where the drug industry is pushing for the bill’s inclusion. The letter argues that if Congress wants to “align” timelines for biologics and pills, as President Trump recently suggested, it should do so at 9 years, not 13, to protect savings for patients and taxpayers. Blocking earlier negotiation would mean drugs like Eliquis and Jardiance, which were negotiated in the first round, would not be eligible, costing Americans billions in higher prices. – [P4ADNow, The Hill, Axios, AARP]
Pharma-Backed Patent Bills Return
Yesterday, Senators Thom Tillis and Chris Coons reintroduced two harmful bills — the PREVAIL Act and PERA — that would entrench pharma monopolies and block lower-cost competition. P4ADNow strongly opposes both bills, which would weaken key patent oversight tools and expand patent protections that keep drug prices high. Patients helped defeat these harmful proposals in the last Congress, and are ready to do it again. With 78% of voters saying drug companies are focused on profits over people, advancing these bills isn’t just bad policy — it’s bad politics. – [P4ADNow, Arnold Ventures]
Pharma Opposes Tariffs — They Prefer to Hike Prices Themselves
The Trump administration’s investigation into pharmaceutical imports has raised the possibility of a 25% tariff on drugs and ingredients. A new PhRMA-commissioned report warns tariffs could raise U.S. drug prices by nearly 13% and cost Americans $51 billion annually — but let’s be clear: drug companies set drug prices, and while we agree tariffs would drive up costs and threaten access, Big Pharma’s warning is more about protecting its bottom line than protecting patients. As P4AD’s Merith Basey told The Lancet Oncology, it’s patients who would suffer the most, facing higher prices, potential shortages, and threats to the progress made under Medicare drug price negotiation. – [Reuters, Consumer Affairs, Pharmaphorum, The Lancet Oncology]
Pharma’s Scapegoat: Inside the $31M Campaign to Shift Blame
A new Wall Street Journal article reveals how Big Pharma’s $31 million lobbying blitz last year, plus another $13 million in Q1 2025, helped shift blame for high drug prices onto pharmacy benefit managers (PBMs). From funding minority-led nonprofits to underwriting conservative media campaigns, the piece exposes how drug companies are shaping the narrative to deflect scrutiny. It’s a calculated strategy that makes strange bedfellows — and while P4AD supports genuine reforms to rein in PBMs, it’s clear the drug industry is more focused on shifting blame and protecting profits than fixing the system. – [The Wall Street Journal]
ICYMI
P4AD released an open letter to our community – on the 100th day of President Trump’s second term – reaffirming our commitment to lowering drug prices. While Pharma ramps up lobbying and pushes carveouts like the EPIC Act, patients are organizing, fighting back, and driving progress. The fight continues.
Subscribe to the WEEK IN REVIEW here.
Welcome to the Week in Review.
NEW POLL: GOP Voters Overwhelmingly Back Medicare Negotiation
A major new poll from Republican polling firm Fabrizio Ward confirms what patients have long known: Voters overwhelmingly support bold action to lower drug prices, and their views are driven by their lived experiences. The survey shows 89% of American voters, including 89% of Trump voters, say prescription drug prices are too high. Nearly 60% have struggled to afford their medications, and a staggering 86% of all voters support Medicare negotiating prices for all prescription drugs by capping prices no higher than what other wealthy nations pay. Support for negotiation jumps to 72% among Republicans, while favorability for pharma is underwater among Trump voters at -43. With Republicans gaining 20 points on the generic ballot when they back Medicare negotiation, the takeaway is clear: Defending Medicare negotiation is not just good policy – it’s good politics. — [Arnold Ventures]
Pharma’s Record-Breaking Lobbying Spend
Big Pharma is spending more than ever to block reforms and protect its monopoly pricing power. PhRMA, the industry’s top lobbying group, reported a record $12.9 million in federal lobbying expenditures in Q1 of 2025 – the most it’s ever spent in a single quarter – to roll back provisions of the 2022 prescription drug law, secure carveouts like the EPIC Act, and keep prices high for patients. The surge in spending also reflects mounting pressure over Trump’s tariff threats, with companies like Pfizer and Eli Lilly sharply increasing their own lobbying budgets and hiring Trump-linked lobbyists to shape policy behind closed doors. Lilly nearly doubled its Q1 spending compared to last year, hitting $3.4 million, while Pfizer jumped to $4.2 million. As one in three Americans struggles to afford their prescriptions, the industry’s multimillion-dollar blitz to preserve its power speaks volumes. — [Endpoints, Sludge, POLITICO, POLITICO]
‘Most Favored Nation’ Pricing Floated For 2nd Time
The Trump administration is reportedly considering a “Most Favored Nation” (MFN) policy that would tie Medicare drug prices to those paid in other wealthy countries, where prices are often dramatically lower. Originally introduced during President Trump’s first term and blocked in court, the MFN proposal would prevent Medicare from paying more than the lowest price charged for a drug in peer nations, adjusted for economic factors. While the concept has some support, it remains deeply unpopular with pharmaceutical companies. Trump’s team is said to be weighing options for reviving the policy through a new Medicare demonstration model or legislation. No formal proposal has been released yet, but recent comments and documents suggest the idea is gaining traction once again. — [STAT News, Reuters, BioSpace, RAND]
Subscribe to the WEEK IN REVIEW here.